Immunology Video Lectures




Immunology: Lecture Series

Presented by HHMI investigators John W. Kappler, Ph.D., and Philippa Marrack, Ph.D.

View the webcast video of the 1996 Holiday Lectures on Science. Choose your connection speed below. Requires RealPlayer.

Lecture One—How Immune Cells Create Trillions of Receptors from a Few Hundred Parts by John W. Kappler, Ph.D.
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Lecture Two—How the Immune System Detects Invaders by Philippa Marrack, Ph.D.
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Lecture Three—How the Host Avoids 'Friendly Fire' by John W. Kappler, Ph.D.
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Lecture Four—Stalking the Elusive Pathogen by Philippa Marrack, Ph.D.
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"The Role of Innate & Adaptive Immunity in the Response to Pathogens"
Dr. Michael Carroll
Professor of Pediatrics & (Pathology) Harvard Medical School,
The CBR Institute for Biomedical Research
Dr. Carroll will describe basic concepts in innate and adaptive immunity and how the two systems work synergistically. His discuss will focus on a murine model in which the innate immune system enhances the antibody response to an infectious viral agent (herpes simplex virus).
"T-cell responses to Microbial Pathogens"
Dr. Michael Starnbach
Department of Microbiology and Molecular Genetics,
Harvard Medical School
Bacterial pathogens have devised a great number of virulence strategies that allow them to successfully use animal hosts to replicate and spread. These strategies also dictate the types of immune responses that are effective at eliminating these organisms. The lecture will focus on how the adaptive immune system responds to bacterial pathogens.
"Harnessing RNA Interference for Therapy"
Dr. Judy Lieberman
Senior Investigator and Professor of Pediatrics,
The CBR Institute for Biomedical Research, Harvard Medical School
RNA interference is a recently described process for silencing gene expression that occurs in all cells. RNA interference uses small double stranded RNAs to target messenger RNAs with homologous sequences for degradation. Dr. Lieberman will discuss how these small RNAs might be used as drugs to treat a variety of human diseases.
"Innate Immunity in Tropical Disease"
Dr. Donald Harn
Professor, Department of Immunology and Infectious Diseases,
Harvard School of Public Health
Dr. Harn will discuss the activation of "immune" cells by a family of oligosaccharides that are expressed on a variety of pathogen surfaces, including the human helminth parasite Schistosoma mansoni. The role of toll-like receptors in immune responses to tropical parasites, and the development of vaccines for infectious diseases of the tropics will also be explored.
"Co-option and Destruction of the Immune System by HIV"
Dr. Robert Lue
Dean of the Harvard Summer School,
Senior Lecturer on Molecular and Cellular Biology,
Director of HHMI Undergraduate & Outreach Programs at Harvard
Conservative estimates indicate that more than 40 million men, women, and children are currently infected with HIV world-wide. The vast majority of these individuals will go on to develop AIDS and become part of the most serious medical crisis in recorded history. Dr. Lue will discuss the diverse ways in which the virus and viral proteins both co-opt and ultimately destroy the human immune system.
"Differentiation and Function of CD4"
Dr. Laurie Glimcher
Higgins Professor of Biochemistry,
Department of Molecular and Cellular Biology
"Natural Killer Cells"
Dr. Jack Strominger
Higgins Professor of Biochemistry,
Department of Molecular and Cellular Biology

Immunology and Cancer

Jianzhu Chen lays out the thorny challenges of harnessing the immune system to fight cancer. He starts with the basics: how the body employs two levels of defense against pathogens: native and adaptive immunity. The latter type of protection specifically interests Chen, because it can recognize and remember “an almost unending number” of specific pathogens, both inside and outside cells.