HHMI Howard Hughes Medical Institute - BioInteractive

Presented by HHMI investigators Joseph S. Takahashi, Ph.D., and Michael Rosbash, Ph.D.,

Biological Clocks: Informal Talks

To Eat or to Sleep

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Masashi Yanagisawa, M.D., Ph.D.
Investigator, University of Texas Southwestern Medical Center at Dallas

Why are people sleepier after they eat and more awake when hungry? Learn about the exciting breakthroughs scientists have made in understanding links between two different brain functions-sleeping and eating. In his talk, Masashi Yanagisawa, M.D., Ph.D., an HHMI investigator at the University of Texas Southwestern Medical Center, describes the essential role of orexins-neuropeptides that regulate appetite-in causing severe sleep disturbances in mice and humans. This 70-minute lecture, videotaped at HHMI headquarters, is enhanced by slides and indexed by content. Lecture "highlights" focus on key topics such as fundamentals of sleep and narcolepsy.

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• Lecture One—Biology in Four Dimensions, by Joseph S. Takahashi, Ph.D.
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• Lecture Two—Unwinding Clock Genetics, by Michael Rosbash, Ph.D.
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• Lecture Three—PERfect TIMing, by Michael Rosbash, Ph.D.
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• Lecture Four—The Mammalian Timekeeper, by Joseph S. Takahashi, Ph.D.
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